Title page for ETD etd-02132009-172025


Type of Document Dissertation
Author Yang, Wei
URN etd-02132009-172025
Title Studies on the structural organization of Golgi complex
Degree PhD
Department Biochemistry and Anaerobic Microbiology
Advisory Committee
Advisor Name Title
Storrie, B. Committee Chair
Bender, Patrick K. Committee Member
Keenan, T. W. Committee Member
Walker, R. A. Committee Member
Wong, E. A. Committee Member
Keywords
  • Secretory proteins
Date of Defense 1995-05-05
Availability restricted
Abstract
Goigi complex is a multi-compartmental organelle involved in posttranslational modification and sorting of secretory proteins. We have characterized the distribution in Vero cells of three Golgi cisternal membrane proteins, Sialyltransferase (SialyIT, tansGolgi/TGN), galactosyltransferase(GalT, trans-GolgiffGN), and Nacetylglucosametransferase-l (GlcNAcT-I, medial-Golgi), during the process of Golgi disassembly and reassembly following the addition or removal of drugs. After 1 h nocodazole (microtubule depolymerizer) treatment, SialylT and GalT were found in scattered punctate structures that increased in number over time as less and less of these proteins were found perinuclearly.
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