Title page for ETD etd-02262002-113508


Type of Document Master's Thesis
Author Zwolak, Jason Walter
Author's Email Address jzwolak@vt.edu
URN etd-02262002-113508
Title Parameter Estimation in Biological Cell Cycle Models Using Deterministic Optimization
Degree Master of Science
Department Computer Science
Advisory Committee
Advisor Name Title
Tyson, John J. Committee Co-Chair
Watson, Layne T. Committee Co-Chair
Heath, Lenwood S. Committee Member
Keywords
  • Cell Cycle Models
  • Parameter Estima- tion.
  • Ordinary Di erential Equations
Date of Defense 2001-10-31
Availability unrestricted
Abstract
Cell cycle models used in biology can be very complex. These models have parameters

with initially unknown values. The values of the parameters vastly a ect the accuracy of the

models in representing real biological cells. Typically people search for the best parameters

to these models using computers only as tools to run simulations. In this thesis methods

and results are described for a computer program that searches for parameters to a series

of related models using well tested algorithms. The code for this program uses ODRPACK

for parameter estimation and LSODAR to solve the di erential equations that comprise the

model.

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