Type of Document Master's Thesis Author Zwolak, Jason Walter Author's Email Address jzwolak@vt.edu URN etd-02262002-113508 Title Parameter Estimation in Biological Cell Cycle Models Using Deterministic Optimization Degree Master of Science Department Computer Science Advisory Committee
Advisor Name Title Tyson, John J. Committee Co-Chair Watson, Layne T. Committee Co-Chair Heath, Lenwood S. Committee Member Keywords
- Cell Cycle Models
- Parameter Estima- tion.
- Ordinary Di erential Equations
Date of Defense 2001-10-31 Availability unrestricted Abstract Cell cycle models used in biology can be very complex. These models have parameterswith initially unknown values. The values of the parameters vastly a ect the accuracy of the
models in representing real biological cells. Typically people search for the best parameters
to these models using computers only as tools to run simulations. In this thesis methods
and results are described for a computer program that searches for parameters to a series
of related models using well tested algorithms. The code for this program uses ODRPACK
for parameter estimation and LSODAR to solve the di erential equations that comprise the
model.
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