Type of Document	Master's Thesis
Author	MacLean, Heidi Norma
URN	etd-03242004-165009
Title	Plasma N-terminal Proatrial Natriuretic Peptide Concentration in Cats with Hypertrophic Cardiomyopathy
Degree	Master of Science
Department	Veterinary Medical Sciences
Advisory Committee	Advisor Name Title Jonathan A. Abbott Committee Chair R. Lee Pyle Committee Member William R. Huckle Committee Member
Keywords	feline diastolic dysfunction hypertrophic cardiomyopathy atrial natriuretic peptide
Date of Defense	2004-03-12
Availability	restricted
Abstract PLASMA N-TERMINAL PROATRIAL NATRIURETIC PEPTIDE CONCENTRATION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY by Heidi N. MacLean Jonathan A. Abbott, Chair (ABSTRACT) Objective: We sought to determine N-terminal proatrial natriuretic peptide concentrations [Nt-proANP] in plasma from cats with hypertrophic cardiomyopathy (HCM). Secondarily, we wished to evaluate the relationship between [Nt-proANP] and echocardiographic variables. Methods: Venous blood samples were obtained from seventeen cats with HCM and from nineteen healthy cats. Plasma [Nt-proANP] was determined using an ELISA assay. The relationship between plasma [Nt-proANP] and M-mode, 2-dimensional and Doppler echocardiographic variables was evaluated. Cats that were hyperthyroid or had evidence of renal disease were excluded from the study. Results: The mean plasma [Nt-proANP] was higher in cats with HCM (3.81 +/- 1.23 pmol/l) than in control cats (3.08 +/- 1.41 pmol/l); however, this difference was not statistically significant (p=0.17). There was a significant correlation between plasma [Nt-proANP] and left ventricular posterior wall thickness (r = 0.42; p=0.01). Additionally, plasma [Nt-proANP] was correlated with left atrial size (r = 0.35; p=0.03). A linear regression model was developed to further explore these relationships. LAs2D and LVPWd had an interactive effect on plasma [Nt-proANP] (R2 = 0.2737; p= 0.02). There was no correlation between any other echocardiographic variable and plasma [Nt-proANP]. There was no correlation between plasma [Nt-proANP] and heart rate (HR), body-weight, or age. Conclusions: Cats with HCM do not have significantly higher plasma [Nt-proANP] than normal cats. There was a significant linear relationship between [Nt-proANP] and LAs2D, LVPWd and the model that described their interaction.
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