| Type of Document |
Master's Thesis |
| Author |
Ward, Deborah Marie
|
| Author's Email Address |
doctor4dogs@aol.com |
| URN |
etd-04052000-18260052 |
| Title |
Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog
|
| Degree |
Master of Science |
| Department |
Veterinary Medical Sciences |
| Advisory Committee |
| Advisor Name |
Title |
| Leib, Michael S. |
Committee Chair |
| Duncan, Robert B. Jr. |
Committee Member |
| Johnston, Spencer A. |
Committee Member |
| Monroe, William Edward |
Committee Member |
|
| Keywords |
- NSAIDs
- dogs
- gastric ulceration
- Aspirin
- misoprostol
|
| Date of Defense |
2000-03-27 |
| Availability |
unrestricted |
Abstract
The effect of reduced frequency of
administration of misoprostol on its ability to
prevent aspirin-induced gastric injury was
evaluated. Twenty-four random-source dogs were
divided into 4 groups which received aspirin
and misoprostol as follows: Group I, 25 mg/kg
aspirin PO TID and placebo PO TID; Group II,
25 mg/kg aspirin PO TID and misoprostol 3 ug/kg
PO TID; Group III, 25 mg/kg aspirin PO TID,
misoprostol 3 ug/kg PO BID and placebo PO QD;
and Group IV, 25 mg/kg aspirin PO TID,
misoprostol 3 ug/kg PO QD and placebo PO BID
for 28 days. Groups were stratified to contain
an equal number of dogs positive or negative for
Helicobacter spp. based on results of 'CLO test'.
Gastroscopy was performed on days -9, 5, 14
and 28. Each region of the stomach was evaluated
separately and visible lesions were scored on a
scale of 1 (submucosal hemorrhage) to 11
(perforating ulcer). The scores for each
region were summed and the median total score
for each group at each day and median total
score within each group between days was compared
using a Kruskal-Wallis test.
No difference in total score was identified
between Group I and IV on any day. Median total
scores for Groups II and III were significantly
(p < 0.05) lower compared to Groups I and IV on
day 5. Significant difference was observed on
Day 14 between the total score of Group III and
Group IV. Group III had a significantly lower
score (p < 0.05) than Groups I, II and IV on day
28. Gastric erosions were present in all groups
in the study. This study suggests that
misoprostol 3 ug/kg PO BID dosing is as effective
as misoprostol 3 ug/kg PO TID dosing at
preventing aspirin-induced gastric injury in
this model. However, misoprostol 3 ug/kg PO
TID dosing was less effective in preventing
aspirin-induced gastric injury on days 14 and 28
than in previous studies. The lack of efficacy of
TID dosing on days 14 and 28 may be related to
higher salicylate concentrations in Group II dogs
or individual variation within the small study
population.
|
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