Experiments were undertaken to study, in vitro and
in vivo, the metabolism or highly chlorinated. naphthalenes by the albino rat and the calf. Three studies were made.
The first involved the determination of the amount of uptake
of hexaehloronaphthalene by rat liver and kidney tissue.
Similar studies on calf liver and kidney also were made.
Secondly, balance studies were conducted, comparing the relative
amounts of hexa- and octachloronaphthalene absorbed
after feeding these compounds to rats. Finally, experiments
were undertaken to investigate the possible formation of conjugated
products as a means of chlorinated naphthalene metabolism.
From the studies, a number of conclusions were derived.
1. In the rat and calf, liver seems to be an active
metabolizing or detoxifying organ as evidenced by uptake of
hexachloronaphthalene by liver of both these animals. Kidney
on the other hand showed no uptake in either animal. Calf
liver has a greater capacity tor hexachloronaphthalene uptake
than does rat liver tissue.
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