Type of Document Master's Thesis Author Zimmerman-Pope, Nancy Author's Email Address firstname.lastname@example.org URN etd-04162003-161335 Title Effect of Fenoldopam on Renal Function in Normal Dogs Following Nephrotomy Degree Master of Science Department Veterinary Medical Sciences Advisory Committee
Advisor Name Title Waldron, Don R. Committee Chair Barber, Donald L. Committee Member Forrester, S. Dru Committee Member Wilcke, Jeffrey R. Committee Member Keywords
- Glomerular Filtration Rate
- Renal Function
Date of Defense 2003-04-24 Availability unrestricted AbstractObjective: To evaluate the effect of fenoldopam on renal function in normal dogs subjected to bisection nephrotomy. In addition, effects of bisection nephrotomy on renal function in normal dogs were evaluated.
Study Design: Controlled, randomized, blinded experiment
Sample Population: Sixteen mixed breed adult dogs
Methods: Dogs were paired for sex, body weight, and approximate age and were assigned to one of two groups: fenoldopam (F) or placebo (P). Baseline glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), urinalysis (UA), and urine culture were performed prior to surgery. A left bisection nephrotomy was performed via a standard midline celiotomy. Dogs in Group F received perioperative intravenous infusion of fenoldopam (0.1 ìg/kg/min) for 90 minutes; dogs in Group P received 0.9 % saline (equivalent volume/kg) for 90 minutes. Body temperature, heart rate, respiration, direct arterial blood pressure, and urine volume were recorded during anesthesia. Renal function was assessed by measuring SCr, BUN, and GFR based on quantitative renal scintigraphy using 99mTc-DTPA at 1, 21, and 42 days after surgery.
Results: There was no significant difference between groups in physiologic parameters assessed. There was no significant difference in GFR, BUN, or SCr between groups or between operated or control kidneys.
Conclusions: Bisection nephrotomy in normal dogs with renal arterial occlusion of 15 minutes and a simple continuous capsular closure does not adversely affect renal function.
Clinical Relevance: Further study investigating perioperative effects of fenoldopam in dogs with existing renal dysfunction is indicated. Bisection nephrotomy, as described in this study, does not decrease renal function as measured by BUN, SCr, or GFR.
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