Title page for ETD etd-04162003-161335


Type of Document Master's Thesis
Author Zimmerman-Pope, Nancy
Author's Email Address nzp@vt.edu
URN etd-04162003-161335
Title Effect of Fenoldopam on Renal Function in Normal Dogs Following Nephrotomy
Degree Master of Science
Department Veterinary Medical Sciences
Advisory Committee
Advisor Name Title
Waldron, Don R. Committee Chair
Barber, Donald L. Committee Member
Forrester, S. Dru Committee Member
Wilcke, Jeffrey R. Committee Member
Keywords
  • Nephrotomy
  • Glomerular Filtration Rate
  • Dog
  • Fenoldopam
  • Renal Function
  • Scinitigraphy
  • Dopamine
Date of Defense 2003-04-24
Availability unrestricted
Abstract
Objective: To evaluate the effect of fenoldopam on renal function in normal dogs subjected to bisection nephrotomy. In addition, effects of bisection nephrotomy on renal function in normal dogs were evaluated.

Study Design: Controlled, randomized, blinded experiment

Sample Population: Sixteen mixed breed adult dogs

Methods: Dogs were paired for sex, body weight, and approximate age and were assigned to one of two groups: fenoldopam (F) or placebo (P). Baseline glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), urinalysis (UA), and urine culture were performed prior to surgery. A left bisection nephrotomy was performed via a standard midline celiotomy. Dogs in Group F received perioperative intravenous infusion of fenoldopam (0.1 ìg/kg/min) for 90 minutes; dogs in Group P received 0.9 % saline (equivalent volume/kg) for 90 minutes. Body temperature, heart rate, respiration, direct arterial blood pressure, and urine volume were recorded during anesthesia. Renal function was assessed by measuring SCr, BUN, and GFR based on quantitative renal scintigraphy using 99mTc-DTPA at 1, 21, and 42 days after surgery.

Results: There was no significant difference between groups in physiologic parameters assessed. There was no significant difference in GFR, BUN, or SCr between groups or between operated or control kidneys.

Conclusions: Bisection nephrotomy in normal dogs with renal arterial occlusion of 15 minutes and a simple continuous capsular closure does not adversely affect renal function.

Clinical Relevance: Further study investigating perioperative effects of fenoldopam in dogs with existing renal dysfunction is indicated. Bisection nephrotomy, as described in this study, does not decrease renal function as measured by BUN, SCr, or GFR.

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