Title page for ETD etd-04282000-11300054


Type of Document Master's Thesis
Author Calzone, Laurence
Author's Email Address lcalzone@math.vt.edu
URN etd-04282000-11300054
Title Mathematical Modeling of the Budding Yeast Cell Cycle
Degree Master of Science
Department Mathematics
Advisory Committee
Advisor Name Title
Tyson, John J. Committee Chair
Rogers, Robert C. Committee Member
Wheeler, Robert L. Committee Member
Keywords
  • cell cycle
  • Budding Yeast
  • CDK
Date of Defense 2000-04-24
Availability unrestricted
Abstract
The cell cycle of the budding yeast, Saccharomyces cerevisiae, is regulated by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), a family of protein kinases that drive the major events of the cell cycle. A previous mathematical model by Chen et al. (2000) described a molecular mechanism for the Start transition (passage from G1 phase to S/M phase) in budding yeast. In this thesis, my main goal is to extend Chen's model to include new information about the mechanism controlling Finish (passage from S/M phase to G1 phase). Using laws of biochemical kinetics, I transcribed the hypothetical molecular mechanism into a set of differential equations. Simulations of the wild-type cell cycle and the phenotypes of more than 60 mutants provide a thorough understanding of how budding yeast cells exit mitosis.

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