Type of Document	Master's Thesis
Author	Calzone, Laurence
Author's Email Address	lcalzone@math.vt.edu
URN	etd-04282000-11300054
Title	Mathematical Modeling of the Budding Yeast Cell Cycle
Degree	Master of Science
Department	Mathematics
Advisory Committee	Advisor Name Title John J. Tyson Committee Chair R. Rogers Committee Member R. Wheeler Committee Member
Keywords	CDK Budding Yeast cell cycle
Date of Defense	2000-04-24
Availability	unrestricted
Abstract The cell cycle of the budding yeast, Saccharomyces cerevisiae, is regulated by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), a family of protein kinases that drive the major events of the cell cycle. A previous mathematical model by Chen et al. (2000) described a molecular mechanism for the Start transition (passage from G1 phase to S/M phase) in budding yeast. In this thesis, my main goal is to extend Chen's model to include new information about the mechanism controlling Finish (passage from S/M phase to G1 phase). Using laws of biochemical kinetics, I transcribed the hypothetical molecular mechanism into a set of differential equations. Simulations of the wild-type cell cycle and the phenotypes of more than 60 mutants provide a thorough understand ing of how budding yeast cells exit mitosis.
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