| Type of Document |
Master's Thesis |
| Author |
Calzone, Laurence
|
| Author's Email Address |
lcalzone@math.vt.edu |
| URN |
etd-04282000-11300054 |
| Title |
Mathematical Modeling of the Budding Yeast Cell Cycle |
| Degree |
Master of Science |
| Department |
Mathematics |
| Advisory Committee |
| Advisor Name |
Title |
| Tyson, John J. |
Committee Chair |
| Rogers, Robert C. |
Committee Member |
| Wheeler, Robert L. |
Committee Member |
|
| Keywords |
- cell cycle
- Budding Yeast
- CDK
|
| Date of Defense |
2000-04-24 |
| Availability |
unrestricted |
Abstract
The cell cycle of the budding yeast, Saccharomyces cerevisiae, is regulated by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), a family of protein kinases that drive the major events of the cell cycle. A previous mathematical model by Chen et al. (2000) described a molecular mechanism for the Start transition (passage from G1 phase to S/M phase) in budding yeast. In this thesis, my main goal is to extend Chen's model to include new information about the mechanism controlling Finish (passage from S/M phase to G1 phase). Using laws of biochemical kinetics, I transcribed the hypothetical molecular mechanism into a set of differential equations. Simulations of the wild-type cell cycle and the phenotypes of more than 60 mutants provide a thorough understanding of how budding yeast cells exit mitosis.
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| Files |
| Filename |
Size |
Approximate Download Time
(Hours:Minutes:Seconds)
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| 28.8 Modem |
56K Modem |
ISDN (64 Kb) |
ISDN (128 Kb) |
Higher-speed Access |
| |
LCThesis.pdf |
514.34 Kb |
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