| Type of Document |
Dissertation |
| Author |
Shojania Feizabadi, Mitra
|
| Author's Email Address |
mfeizaba@vt.edu |
| URN |
etd-05192005-104254 |
| Title |
Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents |
| Degree |
PhD |
| Department |
Physics |
| Advisory Committee |
| Advisor Name |
Title |
| Spillman, William B. Jr. |
Committee Chair |
| Indebetouw, Guy J. |
Committee Member |
| Mizutani, Tetsuro |
Committee Member |
| Ritter, Alfred L. |
Committee Member |
| Walker, Richard A. |
Committee Member |
|
| Keywords |
- antimitotic drugs
- dynamic instability
- microtubule
|
| Date of Defense |
2005-04-29 |
| Availability |
unrestricted |
Abstract
A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.
|
| Files |
| Filename |
Size |
Approximate Download Time
(Hours:Minutes:Seconds)
|
| 28.8 Modem |
56K Modem |
ISDN (64 Kb) |
ISDN (128 Kb) |
Higher-speed Access |
| |
Dissertation.pdf |
541.25 Kb |
00:02:30 |
00:01:17 |
00:01:07 |
00:00:33 |
00:00:02 |
|
