Title page for ETD etd-05232001-192315


Type of Document Dissertation
Author Baloglu, Erkan
URN etd-05232001-192315
Title Synthesis and Biological Evaluation of Paclitaxel Analogs
Degree PhD
Department Chemistry
Advisory Committee
Advisor Name Title
Kingston, David G. I. Committee Chair
Carlier, Paul R. Committee Member
Deck, Paul A. Committee Member
Dorn, Harry C. Committee Member
Tanko, James M. Committee Member
Keywords
  • Cancer
  • Baccatin
  • Combinatorial Chemistry
  • Chemotherapy
  • Microtubules
  • Paclitaxel
  • Taxol
  • Tubulin
  • Anticancer Drugs
Date of Defense 2001-05-11
Availability unrestricted
Abstract
The complex natural product paclitaxel (Taxol®),

first isolated from Taxus brevifolia, is a member

of a large family of taxane diterpenoids.

Paclitaxel is extensively used for the treatment

of solid tumors, particularly those of the breasts

and ovaries. In order to obtain additional

information about the mechanism of action of

paclitaxel and the environment of the

paclitaxel-binding site, several fluorescent

analogs of paclitaxel were synthesized, and

their biological activities have been evaluated. For the investigation of possible synergistic effects, concurrent modifications on selected positions have been performed and their biological evaluation were studied.

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