Type of Document Dissertation Author Baloglu, Erkan URN etd-05232001-192315 Title Synthesis and Biological Evaluation of Paclitaxel Analogs Degree PhD Department Chemistry Advisory Committee
Advisor Name Title Kingston, David G. I. Committee Chair Carlier, Paul R. Committee Member Deck, Paul A. Committee Member Dorn, Harry C. Committee Member Tanko, James M. Committee Member Keywords
- Cancer
- Baccatin
- Combinatorial Chemistry
- Chemotherapy
- Microtubules
- Paclitaxel
- Taxol
- Tubulin
- Anticancer Drugs
Date of Defense 2001-05-11 Availability unrestricted Abstract The complex natural product paclitaxel (Taxol®),first isolated from Taxus brevifolia, is a member
of a large family of taxane diterpenoids.
Paclitaxel is extensively used for the treatment
of solid tumors, particularly those of the breasts
and ovaries. In order to obtain additional
information about the mechanism of action of
paclitaxel and the environment of the
paclitaxel-binding site, several fluorescent
analogs of paclitaxel were synthesized, and
their biological activities have been evaluated. For the investigation of possible synergistic effects, concurrent modifications on selected positions have been performed and their biological evaluation were studied.
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