Type of Document Master's Thesis Author Yocum, Susan Marie URN etd-06102012-040408 Title Effects of low level lead and cadmium on reproduction in Peromyscus leucopus and a study of lead concentration in small mammals from old orchards Degree Master of Science Department Fisheries and Wildlife Sciences Advisory Committee
Advisor Name Title Scanlon, Patrick F. Committee Chair Kirkpatrick, Roy L. Committee Member Vaughan, Michael R. Committee Member Keywords
Date of Defense 1988-03-15 Availability restricted AbstractLead and cadmium frequently occur together as contaminants in polluted environments such
as roadsides, urban areas, mines, and smelters. Few studies have been conducted to
examine the possible interactive effects these metals may have on reproduction of wild
The first part of this study was directed toward examining the effects of low level dietary lead
and cadmium on reproduction in Peromyscus Jeucopus. Two laboratory studies were
conducted. Treatment with combinations of 0, 1 or 4 μ/g lead acetate and/or cadmium
chloride was found to have no effect on overall health or reproductive ability of white-footed
mice. In a second, experiment mice were treated with combinations of 0 or 10 μg/g lead
acetate and/or cadmium' chloride. Treatment was continued through three generations of
mice (P1, Fl, F2); progeny of the P1 were paired with nonrelatives in the same group and
continued on the same treatment. Percentage-of pairs producing at least one litter in a ten
week period was reduced in mice receiving both lead and cadmium. By the F2 generation
only one of ten pairs produced offspring. There were minor variations in litter parameters (# pups/litter, birth weight, weanling weight and viability of litters) measured for the three
generations; however, treatment did not appear to greatly affect litters in those pairs which
had litters. In the P1 generation kidney weights were lower in mice receiving lead and
epididymidis weight was higher in mice receiving cadmium. Mice (P1) receiving cadmium and lead had lower numbers of spermatozoa/mg testis. Lead content of carcass, liver and kidneys
was analyzed in mice from the P1 generation.
The second part of this study examined the persistence of lead in the environment after the
source of contamination has been removed. Short-tailed shrews (Blarina brevicauda) trapped
in an orchard with a history of lead arsenate use had higher whole body lead concentrations
than individuals of the same species trapped in a control orchard. Within the treated orchard
lead concentrations in pine voles (Microtus pinetorum) were significantly higher than
concentrations in short-tailed shrews.
Filename Size Approximate Download Time (Hours:Minutes:Seconds)
28.8 Modem 56K Modem ISDN (64 Kb) ISDN (128 Kb) Higher-speed Access LD5655.V855_1988.Y648.pdf 4.86 Mb 00:22:30 00:11:34 00:10:07 00:05:03 00:00:25next to an author's name indicates that all files or directories associated with their ETD are accessible from the Virginia Tech campus network only.
If you have questions or technical problems, please Contact DLA.