Title page for ETD etd-06132000-18060049


Type of Document Master's Thesis
Author Giroux, Alain G
URN etd-06132000-18060049
Title A New Device for Stereotactic ct-Guided Biopsy of the Canine Brain: Design, Construction, and Needle Placement Accuracy
Degree Master of Science
Department Veterinary Medical Sciences
Advisory Committee
Advisor Name Title
Jones, Jeryl C. Committee Chair
Bohn, Jan Helge Committee Member
Duncan, Robert B. Jr. Committee Member
Inzana, Karen D. Committee Member
Waldron, Don R. Committee Member
Keywords
  • Dog
  • Stereotactic Biopsy
  • Canine
  • CT
  • Computed Tomography
Date of Defense 2000-05-31
Availability unrestricted
Abstract
ACCURACY OF A NEW DEVICE FOR STEREOTACTIC

CT-GUIDED BIOPSY OF THE CANINE BRAIN

Alain Giroux, DVM

Jeryl Jones, DVM, PhD, chair

Department of Radiology

ABSTRACT

Computed tomography (CT) is an imaging technique that uses x-ray and computers to create cross-sectional images of structures. Stereotactic CT-guided biopsy is defined as the use of a stable apparatus to direct and perform tissue biopsies under CT guidance. For the brain, the principal advantage of stereotactic CT guidance over other biopsy techniques is its high accuracy in getting a sample from deep-seated lesions. The objectives of this study were to create an inexpensive CT-guided stereotactic device adaptable to different canine head sizes and to test the accuracy of the device for needle placement in deep-seated brain targets. A biopsy device was created that consists of four main components: a CT table fixation device, a head fixture, a needle fixture , and motion control system. Accuracy was tested using 16 head and neck specimens obtained from dogs euthanitized for reasons unrelated to the brain. Deep-seated (caudate nucleus and pituitary gland) targets were identified on CT. After a 5 mm craniotomy, the biopsy needle, with CT monitoring, was progressively introduced into the target. The final needle track distance was measured on CT. The brain was removed and sliced to verify placement of the needle tip within the target and to measure the actual needle track distance. The total cost of materials and construction for the stereotactic CT-guided biopsy device was $785.00. No difference in needle placement accuracy was identified for caudate and pituitary targets. Based on assessments by 2 independent observers, the caudate target was successfully hit 75% of the time. Pituitary targets were successfully hit 96.8 % of the time. Actual needle track lengths were an average of 3.2 mm less that the track length measured on CT. This difference was most likely due to incomplete staining of the bevel part of the needle track on gross specimens.

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