Title page for ETD etd-07102006-161019


Type of Document Master's Thesis
Author Sanna, Chaitanya Ramesh
URN etd-07102006-161019
Title Patterns of Two Types of Overlapping Genes in Five Mammalian Genomes
Degree Master of Science
Department Computer Science
Advisory Committee
Advisor Name Title
Zhang, Liqing Committee Chair
Heath, Lenwood S. Committee Member
Tu, Zhijian Jake Committee Member
Keywords
  • 3'- UTR
  • overlapping genes
  • same strand
  • different strand
  • 5'-UTR
Date of Defense 2006-06-28
Availability restricted
Abstract
Increasing evidence suggests that overlapping genes is a common phenomenon in eukaryotic genomes too and are not restricted to prokaryotes alone. Here we determined overlapping genes in a set of orthologous genes in the genomes of human, chimp, mouse, rat, and dog and contrasted the patterns of overlapping between two principal types of overlapping genes, the same-strand-overlapping genes and different-strand-overlapping genes. The two types of overlapping genes are compared with respect to their frequencies, overlap lengths, region of overlap, and conservation of overlap in five species. Our results suggest the following: different-strand-overlaps are more common, both types show different patterns with respect to overlap lengths and regions of overlap, different-strand-overlapping genes are more evolutionarily conserved, and 3'-UTR evolution plays an important role in transitions between non-overlapping genes and overlapping genes.

The thesis also presents a review of related work in terms of history, origin, types, biological significance of overlapping genes, human diseases associated with them, and their comparison in prokaryotes and eukaryotes.

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