Title page for ETD etd-07122007-163551


Type of Document Master's Thesis
Author Wood, Melinda Anne
URN etd-07122007-163551
Title The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs
Degree Master of Science
Department Biomedical and Veterinary Sciences
Advisory Committee
Advisor Name Title
Panciera, David L. Committee Chair
Berry, Stephanie H. Committee Member
Monroe, William Edward Committee Member
Keywords
  • non-thyroidal illness
  • isoflurane
  • hypothyroidism
  • Thyroxine
Date of Defense 2007-07-02
Availability restricted
Abstract
Background: Many non-thyroidal factors affect thyroid function tests. Anesthesia and surgery have been documented to affect thyroid function tests in humans but have not been extensively studied in dogs.

Hypothesis: Anesthesia alone and anesthesia combined with surgery will affect thyroid function tests in dogs.

Animals: 15 euthyroid mongrel dogs.

Methods: Dogs were assigned to one of three groups: control, general anesthesia, and general anesthesia plus abdominal exploratory surgery. Blood samples were collected from each dog immediately prior to pre-medication, 20 minutes after pre-medication, 55 minutes after anesthesia induction, once daily for an additional 6 days, and 14 days post-procedures. Sampling was performed at identical times in the control group. Thyroxine (T4), free T4 (fT4) by equilibrium dialysis, triiodothyronine (T3), reverse T3 (rT3) and thyroid-stimulating hormone (TSH) concentrations were measured in all samples.

Results: Results of all thyroid function tests were not significantly different between control and anesthesia groups. Serum T3 for the surgery group decreased significantly from baseline compared to the control and anesthesia groups at multiple times. Serum T4 and rT3 for the surgery group increased significantly from baseline compared to the control and anesthesia groups at multiple times. Serum fT4 for the surgery group increased significantly from baseline compared to the control and anesthesia groups at 48 hours only.

Conclusions and Clinical Importance: Surgery has a significant effect on thyroid function tests, while the anesthetic protocol used in this study does not. Because serum T4 and fT4 concentrations increased rather than decreased, evaluating these hormones following surgery is unlikely to lead to a misdiagnosis of hypothyroidism in euthyroid dogs.

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