A study was conducted to determine the effects of
trenbolone acetate (TBA) and estradiol-17B (E2) implantation
on the characteristics of the glucocorticoid and E2
receptor, skeletal muscle protein turnover and tissue
growth. Twenty-four lambs were utilized. Trenbolone
acetate did not ,affect (P>.10) degradation rates in the
semitendinosus (ST) and triceps brachii (TB) muscles, the
production of cortisol, adrenal weights and cytosolic
glucocorticoid binding capcity (Bmax). Trenbolone acetate
decreased synthesis rate of muscle protein (P<.Ol), the
percent of [3H] dexamethasone binding in the nuclear
fraction, Bmax and the disociation constant (Kd) of the
cytosolic E2 receptor, only in the TB muscle.
Deoxyribonucleic acid (DNA) of the TB was increased (P<.05)
with TBA. Pituitary weights were decreased (P<.005) with
TBA and increased (P<.Ol) with E2. Estradiol decreased
(P<.05) Bmax of the cytosolic E2 receptor in the ST and
decreased (P<.05) Bmax of the nuclear E2 receptor in the TB
muscle. The TB muscle had greater (P<.05) synthesis rates
than the ST and the protein:RNA ratio was decreased (P<.05)
in the TB. The TB muscle had greater (P<.005) Bmax for the
cytosolic glucocorticoid receptor.
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