Type of Document Master's Thesis Author Hundley, Stephen Gilbert URN etd-07242012-040021 Title The transfer of endrin via the milk to pine mouse pups and the resultant effects on hepatic microsomal activity. Degree Master of Science Department Biochemistry and Nutrition Advisory Committee
Advisor Name Title Webb, Ryland E. Committee Chair Campbell, T. Colin Committee Member Eaton, John L. Committee Member Keywords
- Pitymys pinetorum
Date of Defense 1974-08-05 Availability restricted AbstractMany lipophilic pesticides are known to be transferred to offspring via the mother's milk. The present study was conducted to determine how much endrin was transferred from endrin resistant and susceptible dams to their suckling pups and to further characterize the effects that endrin may have on the hepatic mixed function oxidase (MFO) system in the pups.
Dosing of the dams with endrin began one day after birth with either (l) oral doses of endrin in corn oil or (2) a mixture of endrin in ground feed. The total amount of endrin in the pup was determined by gas chromatography. MFO activity was determined in 2-1/2 week old pups and for adult animals using maximal activities for the demethylation of ethylmorphine and hydroxylation of aniline.
No difference in the amount of endrin present in the pups was observed between strains provided both received equal amounts of endrin. MFO activity for endrin dosed mature animals and for 2-1/2 week old pups from endrin dosed dams exhibited a significant decrease from control activities. There was no difference in MFO activities between age groups. A significantly higher ethylmorphine demethylase activity was observed in comparing the resistant to the susceptible strain but there was no significant difference in aniline hydroxylase activity.
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