Robert J. Taylor and Herbert A. David developed a new
experimental approach in the screening of prospective drugs
to be used in the treatment of cancer. The procedure is a
sequential one, where the allocation of patients to drugs is
based upon the performance of the drugs in immediately
previous periods. Taylor further developed a computer program
to study the effectiveness of the procedure by means of
simulated trials.
The purpose of this paper has been to study the sequential
allocation procedure further by means of simulation in
the form of a factorial experiment. Of primary concern has
been the behavior of different weighting functions operating
under varying experimental conditions. Response variables
have been studied as a means for evaluating the effectiveness
of the procedure. The results of this experiment are
comparable with the findings originally presented by Taylor and David.
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