Title page for ETD etd-08212001-145348


Type of Document Master's Thesis
Author Williams, R. Lee
Author's Email Address rowilli7@vt.edu
URN etd-08212001-145348
Title Ruthenium-Platinum Polypyridyl Complexes: Synthesis and Characterization
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
Brewer, Karen J. Committee Chair
Deck, Paul A. Committee Member
Tissue, Brian M. Committee Member
Winkel, Brenda S. J. Committee Member
Keywords
  • ruthenium
  • DNA
  • cisplatin
  • bridging ligand
  • platinum
  • polymetallic
  • polyazine
  • polypyridyl
Date of Defense 2001-04-09
Availability restricted
Abstract
A series of bimetallic (RuII, PtII) complexes were synthesized with the general formula [(tpy)RuCl(BL)PtCl2](PF6) (tpy = 2,2':6',2"-terpyridine and BL = bridging ligand) and their spectroscopic, electrochemical, and DNA binding properties studied. The bridging ligands used in these complexes were 2,3-bis(2'-pyridyl)pyrazine (dpp), 2,3-bis(2'-pyridyl)quinoxaline (dpq) and 2,3-bis(2'-pyridyl)benzoquinoxaline (dpb). These complexes combine light-absorbing RuII-polypyridyl chromophores and a cis-PtCl2 structural motif known to bind DNA. The Ru-bound chloride may be substituted, enabling further modification of the spectroscopic properties. The synthesis of [(tpy)RuCl(BL)PtCl2](PF6) utilizes a building block approach that allows modifications to the series of complexes within the general synthetic scheme. This illustrates the applicability of this scheme to the development of new series of complexes.

The lowest-energy absorption for the three complexes is assigned to a Ru(dp)-to-BL(p*) charge transfer transition. This transition shifts to lower energy as the ligand is varied from dpp to dpq to dpb. The first and second reductions are BL(0/-) and BL(-/2-) based and shift to more positive potentials from dpp to dpq to dpb. The Ru(II/III) redox couple remains at a nearly constant potential for the series. All three compounds show DNA binding when incubated with linearized plasmid DNA. Adduct formation was assessed by agarose gel electrophoresis as a retardation of band migration.

when incubated with linearized plasmid DNA. Adduct formation was assessed by agarose gel electrophoresis as a retardation of band migration.

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