| Type of Document |
Master's Thesis |
| Author |
Zhang, Lin
|
| URN |
etd-09052008-130704 |
| Title |
The involvement of IRAK-1 in the regulation of NFATc2 in T cells |
| Degree |
Master of Science |
| Department |
Biology |
| Advisory Committee |
| Advisor Name |
Title |
| Li, Liwu |
Committee Chair |
| Gogal, Robert M. Jr. |
Committee Member |
| Good, Deborah Jean |
Committee Member |
| Melville, Stephen B. |
Committee Member |
|
| Keywords |
- NFATc2
- adaptive immunity
- IRAK-1
- Foxp3
- signal transduction
|
| Date of Defense |
2008-08-29 |
| Availability |
unrestricted |
Abstract
Interleukin-1 receptor associated kinase -1 is a protein kinase pivotal in mediating signals for innate immune responses. Here, I report that IRAK-1 also regulates cell-mediated immune responses. NFATc2 (nuclear factor of activated T cells) was found to be associated with IRAK-1 in T cells in vitro and its activity was elevated in the absence of IRAK-1. In addition, IRAK-1-/- mice had increased naturally occurring regulatory T cells and inducible regulatory T cells as well as Th1 responses as compared to WT mice. The findings suggest that activated T cells might employ IRAK-1 to mediate the regulation of acquired immunity. Therefore, IRAK-1 may participate in direct signaling cross talk between the innate and the acquired immunity.
|
| Files |
| Filename |
Size |
Approximate Download Time
(Hours:Minutes:Seconds)
|
| 28.8 Modem |
56K Modem |
ISDN (64 Kb) |
ISDN (128 Kb) |
Higher-speed Access |
| |
thesis101508.pdf |
1.99 Mb |
00:09:12 |
00:04:44 |
00:04:08 |
00:02:04 |
00:00:10 |
|
