The performance of a Hewlett Packard Particle Beam
LC/MS interface is evaluated using EPA appendix VIII and
IX compounds. The behavior of these priority pollutants
in the interface could determine its feasibility as a
future EPA certified technique.
The evaluation process consists of studies to
determine minimum detectable quantities (MDQ), linear
response, and band broadening contributions. The MDQ's
of the analytes in electron impact and chemical
ionization modes are extrapolated from experimental
signal to noise data. The linearity study involves ten
compounds analyzed at five different concentrations. The
response factors (RF) are calculated and discussed. The
study concerning the band broadening contributions of
the interface involves four independent variables (helium
flow, desolvation chamber temperature, source
temperature, and 96 methanol) and their effects on peak
width. A Box—Behnken experimental design is used and
described. Response surfaces are generated from the best
fit equation describing the data.
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