Title page for ETD etd-09082012-040648


Type of Document Master's Thesis
Author Cadorette, Veronica R.
URN etd-09082012-040648
Title Chemical investigation of Dicranum fulvum for anticancer activity
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
Kingston, David G. I. Committee Chair
Bell, Harold M. Committee Member
Taylor, Larry T. Committee Member
Keywords
  • Bryophytes
Date of Defense 1989-08-15
Availability restricted
Abstract

Biological screening of extracts of various bryophytes showed that the species Dicranum fulvum gave extracts with activity in both in vitro and in vivo bioassays. This plant was thus selected for extraction and fractionation, monitored by iin vitro bioassays.

Isolation was guided by a combination of bioassay and chemical methods, and led to the isolation of three compounds, betulin, 9,l9- cyclolanost—23—ene—3,25—diol, and B-sitosterol. Purification was achieved by open column, flash column, gel filtration, thin layer chromatography, the chromatotron and crystallization.

The isolated compounds were identified by comparisons of spectroscopic data with those of authentic samples and the matching of experimental and literature melting points and optical rotations.

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