Type of Document	Master's Thesis
Author	Cadorette, Veronica R.
URN	etd-09082012-040648
Title	Chemical investigation of Dicranum fulvum for anticancer activity
Degree	Master of Science
Department	Chemistry
Advisory Committee	Advisor Name Title Kingston, David G. I. Committee Chair Bell, Harold M. Committee Member Taylor, Larry T. Committee Member
Keywords	Bryophytes
Date of Defense	1989-08-15
Availability	restricted
Abstract Biological screening of extracts of various bryophytes showed that the species Dicranum fulvum gave extracts with activity in both in vitro and in vivo bioassays. This plant was thus selected for extraction and fractionation, monitored by iin vitro bioassays. Isolation was guided by a combination of bioassay and chemical methods, and led to the isolation of three compounds, betulin, 9,l9- cyclolanost—23—ene—3,25—diol, and B-sitosterol. Purification was achieved by open column, flash column, gel filtration, thin layer chromatography, the chromatotron and crystallization. The isolated compounds were identified by comparisons of spectroscopic data with those of authentic samples and the matching of experimental and literature melting points and optical rotations.
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