Title page for ETD etd-10042006-143914


Type of Document Dissertation
Author Yang, Bing
URN etd-10042006-143914
Title Action at a distance for specific repression of the glpD and glpTQ genes, and organization of the glpEGR genes of Escherichia coli K-12
Degree PhD
Department Biochemistry
Advisory Committee
Advisor Name Title
Larson, Timothy J. Committee Chair
Boyle, S. M. Committee Member
Gregory, E. M. Committee Member
Niehaus, Walter G. Committee Member
Sitz, Thomas O. Committee Member
Keywords
  • Transcription
  • Regulation
  • Glycerol
  • Repression
  • E. coli
Date of Defense 1997-01-15
Availability restricted
Abstract
Aerobic sn-glycero13-phosphate (glycerol-P) dehydrogenase is a cytoplasmic membrane-associated respiratory enzyme encoded by the g/pD gene of Escherichia coli. The divergently transcribed glpACB and glpTQ operons encode the subunits of the

anaerobic glycerol-P dehydrogenase, glycerol-P transporter, and glycerophosphodiesterase, respectively.

The glpD operon is controlled by cooperative binding of glp repressor (GlpR) to tandem operators that cover the -10 promoter element and 30 bp downstream of the transcription start site. The glpACB-glpTQ operons operons are controlled by GlpR binding to operators that overlap the glpA promoter elements. In this study, two additional operators were identified within the glpD structural gene, and three additional operators were identified within the glpT structural gene.

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