Title page for ETD etd-10132005-152520
|Type of Document
||The application of thin film planar waveguides as a refractive index detector for microscale high performance liquid chromatography
|Dessy, Raymond E.
|Anderson, Mark R.
|Mason, John G.
|Merola, Joseph S.
|Viers, Jimmy W.
- Liquid chromatograph
- yFiber optics
|Date of Defense
Thin film planar waveguides were originally introduced in microwave
engineering. The spectroscopist began to use such waveguides as tools to solve
chemical characterization problems since Harrick and Fahrenfort introduced the
Attenuated Total'Reflection (ATR) in the early 1960's. Today, planar waveguides are
playing an important and ever-increasing role in modem chemistry.
In this thesis, a novel design for a refractometer involving the application of a
thin film planar waveguide and coupling prism was demonstrated. This device shows
the feasibility of refractive index measurements in a flowing stream. Therefore, an online
detector for High Performance Liquid Chromatography (HPLC) was chosen as the
vehicle to test out the concepts.
The research works were devoted to studies of waveguide properties and flow
dynamics in a chromatographic situation. It was found that microscale detection is
possible. The sensitivity can be enhanced by using the highest propagation mode as the
probe, and by selecting a proper refractive index liquid as the solvent carrier.
A description of the investigation and the various factors involved in designing
and optimizing a planar waveguide for refractive index detection is included. The
results provide guidelines for the device as a realistic analytical detector.
|| Approximate Download Time
| 28.8 Modem
|| 56K Modem
|| ISDN (64 Kb)
|| ISDN (128 Kb)
|| Higher-speed Access
next to an author's name indicates that all
files or directories associated with their ETD
are accessible from the Virginia Tech campus network only.
If you have questions or technical
problems, please Contact DLA.