Title page for ETD etd-10132010-152742


Type of Document Master's Thesis
Author Xu, Zhibing
Author's Email Address
URN etd-10132010-152742
Title Synthesis of Paclitaxel Analogs
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
David G. I. Kingston Committee Chair
Paul R. Carlier Committee Member
Webster L. Santos Committee Member
Keywords
  • Myelosuppression
  • beta-Lactam
  • Baccatin
  • Inflammation
  • 2-Methoxyestradiol
  • Tubulin
  • Anticancer Drugs
  • Cancer
  • Paclitaxel
  • Antagonists
Date of Defense 2010-09-30
Availability unrestricted
Abstract
Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3′ and C4 paclitaxel analogs have been synthesized and their biological evaluation have been studied.
Files
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  Final.pdf 2.73 Mb 00:12:37 00:06:29 00:05:40 00:02:50 00:00:14

Browse All Available ETDs by ( Author | Department )

dla home
etds imagebase journals news ereserve special collections
virgnia tech home contact dla university libraries

If you have questions or technical problems, please Contact DLA.