Type of Document Master's Thesis Author Bruns, Nicholas Joseph URN etd-11152013-040457 Title Vitamin A deficiency, serum cortisol and immunoglobulin G levels in lambs Degree Master of Science Department Animal Science Advisory Committee
Advisor Name Title K. E. Webb, Jr. Committee Chair E. T. Kornegay Committee Member F. D. McCarthy Committee Member Klaus D. Elgert Committee Member Keywords
Date of Defense 1986-04-05 Availability restricted AbstractSerum cortisol and immunoglobulin G (IgG>
concentrations were measured to investigate the
relationship between vitamin A status and immune function in lambs. Twenty-four crossbred ewe lambs were each fed 900 g·d-1 of a carotene—deficient diet composed of 95.5% whole
oats, 3% molasses, .5% trace mineral salt and 1% limestone. All lambs were injected monthly with vitamins D and E and
with selenium. The 12 control lambs also received a 100,000 IU oral dose of vitamin A palmitate in capsule form every 2
wk. All lambs were challenged by injecting them with 1 mg ovalbumin in 1 ml of Freund’s complete adjuvant. At the time of challenge, serum vitamin A levels for the control and A-deficient (A—def) lambs were 33.3 and 3.1 ug·dl-1
respectively. Blood was collected prior to and 6, 13, 20 and 34 d post—challenge. The lambs were then re—challenged using the same antigen and blood was obtained 1, 2, 6 and 22 d post—challenge. Lambs were sacrificed at the end of the second challenge period. Spleen weights were obtained and gross post—mortem observations were made at this time.
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