Type of Document Dissertation Author Cahilly, Glenn Moylan URN etd-11152013-040545 Title The effect of thyroxine on protein biosysnthesis and ribonucleic acid metabolism in the rat Degree PhD Department Biochemistry and Nutrition Advisory Committee
Advisor Name Title Clemenbs J. Ackerman Committee Chair Robert R. Schmidt Committee Member Russell F. Miller Committee Member Keywords
- Thyroid hormones
Date of Defense 1964-01-15 Availability restricted Abstract
Thyroxine was observed to stimulate the incorporation of radiolabeled amino acids into protein of cell-free Liver systems from treated normal and hypothyroid rats. However, the in vitro addition of the hormone only had a stimulatory effect, though quite erratic in magnitude, on the normal system. This difference in response has not been explained.
The hypothyroid rat was also characterized by lowered liver ribonucleic acid levels. It WEB found that thyroxine pretreatment resulted in increased ribonucleic acid levels only in the hypothyroid rat with the greater increase occurring in microsomal ribonucleic acid. No change was observed in the ribonucleic acid base ratios of the hypothyroid rat when compared to those of the normal. However, thyroxine pretreatment cf the hypothyroid rat did alter the rate of incorporation of radio phosphorus into the various nucleotides, although there was little difference in the total amount of incorporated label.
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