Title page for ETD etd-12072005-110557

Type of Document

Dissertation

Author

Adou, Eba

URN

etd-12072005-110557

Title

I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE

Degree

PhD

Department

Chemistry

Advisory Committee

Advisor Name	Title
Dr. David G. I. Kingston	Committee Chair
Deck, Paul	Committee Member
Etzkorn, Felicia	Committee Member
Long, Timothy	Committee Member
Tanko, James M.	Committee Member

Keywords

Lucilactaene
Anticancer agents
Cytotoxicity assay
Indole alkaloids
p53 Tumor suppressor Gene
Physalins
Cardenolide glycosides
Diterpenoids
Cucurbitacins
Cell cycle
Cell cycle inhibitor

Date of Defense

2005-11-28

Availability

unrestricted

Abstract

ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA AND A SYNTHETIC APPROACH TO LUCILACTAENE

ABSTRACT

Eba Adou

As part of an International Cooperative Biodiversity Group (ICBG), extracts of plants from Suriname and Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive compounds which were characterized by spectroscopy methods. Craspidospermum verticillatum (Apocynaceae) yielded four known indole alkoids. Casimirella sp (Icacinaceae) gave three new and five known diterpenoids. Pentopetia androsaemifolia (Apocynaceae) afforded one new and three known cardenolide glycosides. Physalis angulata (Solanaceae) yielded seven known physalins. Roupellina boivinnii (Apocynaceae) yielded four known and three new cardenolide glycosides, and three known cucurbitacins were isolated from Octolepis aff. dioica (Thymelaeaceae).
In addition to these structural studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed.

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