Title page for ETD etd-12072005-110557


Type of Document Dissertation
Author Adou, Eba
URN etd-12072005-110557
Title I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE
Degree PhD
Department Chemistry
Advisory Committee
Advisor Name Title
Kingston, David G. I. Committee Chair
Deck, Paul A. Committee Member
Etzkorn, Felicia A. Committee Member
Long, Timothy E. Committee Member
Tanko, James M. Committee Member
Keywords
  • Lucilactaene
  • Anticancer agents
  • Cytotoxicity assay
  • Indole alkaloids
  • p53 Tumor suppressor Gene
  • Physalins
  • Cardenolide glycosides
  • Diterpenoids
  • Cucurbitacins
  • Cell cycle
  • Cell cycle inhibitor
Date of Defense 2005-11-28
Availability unrestricted
Abstract
ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA AND A SYNTHETIC APPROACH TO LUCILACTAENE

ABSTRACT

Eba Adou

As part of an International Cooperative Biodiversity Group (ICBG), extracts of plants from Suriname and Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive compounds which were characterized by spectroscopy methods. Craspidospermum verticillatum (Apocynaceae) yielded four known indole alkoids. Casimirella sp (Icacinaceae) gave three new and five known diterpenoids. Pentopetia androsaemifolia (Apocynaceae) afforded one new and three known cardenolide glycosides. Physalis angulata (Solanaceae) yielded seven known physalins. Roupellina boivinnii (Apocynaceae) yielded four known and three new cardenolide glycosides, and three known cucurbitacins were isolated from Octolepis aff. dioica (Thymelaeaceae).

In addition to these structural studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed.

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