Type of Document Dissertation Author Allen, Nicholas Alexander URN etd-12122005-110907 Title Computational Software for Building Biochemical Reaction Network Models with Differential Equations Degree PhD Department Computer Science Advisory Committee
Advisor Name Title Shaffer, Clifford A. Committee Chair Heath, Lenwood S. Committee Member Ramakrishnan, Naren Committee Member Tyson, John J. Committee Member Watson, Layne T. Committee Member Keywords
- systems biology
- biological modeling
- modeling process
- modeling support environment
Date of Defense 2005-11-11 Availability unrestricted AbstractThe cell is a highly ordered and intricate machine within which a wide variety of chemical processes take place. The full scientific understanding of cellular physiology requires accurate mathematical models that depict the temporal dynamics of these chemical processes. Modelers build mathematical models of chemical processes primarily from systems of differential equations. Although developing new biological ideas is more of an art than a science, constructing a mathematical model from a biological idea is largely mechanical and automatable.
This dissertation describes the practices and processes that biological modelers use for modeling and simulation. Computational biologists struggle with existing tools for creating models of complex eukaryotic cells. This dissertation develops new processes for biological modeling that make model creation, verification, validation, and testing less of a struggle. This dissertation introduces computational software that automates parts of the biological modeling process, including model building, transformation, execution, analysis, and evaluation. User and methodological requirements heavily affect the suitability of software for biological modeling. This dissertation examines the modeling software in terms of these requirements.
Intelligent, automated model evaluation shows a tremendous potential to enable the rapid, repeatable, and cost-effective development of accurate models. This dissertation presents a case study that indicates that automated model evaluation can reduce the evaluation time for a budding yeast model from several hours to a few seconds, representing a more than 1000-fold improvement. Although constructing an automated model evaluation procedure requires considerable domain expertise and skill in modeling and simulation, applying an existing automated model evaluation procedure does not. With this automated model evaluation procedure, the computer can then search for and potentially discover models superior to those that the biological modelers developed previously.
Filename Size Approximate Download Time (Hours:Minutes:Seconds)
28.8 Modem 56K Modem ISDN (64 Kb) ISDN (128 Kb) Higher-speed Access nallen.pdf 1.77 Mb 00:08:11 00:04:12 00:03:41 00:01:50 00:00:09
If you have questions or technical problems, please Contact DLA.