Title page for ETD etd-12132011-141151


Type of Document Master's Thesis
Author Srinivasaraghavan, Vaishnavi
URN etd-12132011-141151
Title A Microfabricated Bioimpedance Sensor with Enhanced Sensitivity for Early Breast Cancer Detection
Degree Master of Science
Department Electrical and Computer Engineering
Advisory Committee
Advisor Name Title
Agah, Masoud Committee Chair
Strobl, Jeannine S. Committee Member
Subbiah, Elankumaran Committee Member
Keywords
  • SAHA
  • Biosensor
  • Microelectrodes
  • Breast Cancer
  • Bioimpedance
Date of Defense 2011-12-01
Availability restricted
Abstract
Bioimpedance is the term given to the complex impedance value that is characteristic of the resistance that biological cells offer to the flow of electric current. The objective of this study is to analyze the differences in the bioimpedance of highly metastatic MDA-MB-231 and normal MCF 10A breast epithelial cells and use this information to detect a very small number of breast cancer cells present in a background of normal breast cells and other cells that are typically present in a human biopsy sample.To accomplish this, a bioimpedance sensor with flat gold microelectrodes on a silicon substrate was designed and fabricated. Suberoylanilide hydroxamic acid (SAHA), an FDA-approved anti-cancer agent was used to improve the sensitivity of the bioimpedance sensor towards cancer cells by selectively modifying their cytoarchitecture.
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