Title page for ETD etd-12142012-115546


Type of Document Master's Thesis
Author Arat, Seda
Author's Email Address sedag@vt.edu
URN etd-12142012-115546
Title A Mathematical Model of a Denitrification Metabolic Network in Pseudomonas aeruginosa
Degree Master of Science
Department Mathematics
Advisory Committee
Advisor Name Title
Laubenbacher, Reinhard C. Committee Chair
Burns, John A. Committee Member
Ciupe, M. Stanca Committee Member
Keywords
  • Discrete Models
  • Systems Biology
  • Dynamical Systems
Date of Defense 2012-11-30
Availability restricted
Abstract
Lake Erie, one of the Great Lakes in North America, has witnessed recurrent summertime low oxygen dead zones for decades. This is a yearly phenomenon that causes microbial production of the greenhouse gas nitrous oxide from denitrification. Complete denitrification is a microbial process of reduction of nitrate to nitrogen gas via nitrite, nitric oxide, and greenhouse gas nitrous oxide. After scanning the microbial community in Lake Erie, Pseudomonas aeruginosa is decided to be examined, not because it is abundant in Lake Erie, but because it can perform denitrification under anaerobic conditions. This study focuses on a mathematical model of the metabolic network in Pseudomonas aeruginosa under denitrification and testable hypotheses generation using polynomial dynamical systems and stochastic discrete dynamical systems. Analysis of the long-term behavior of the system changing the concentration level of oxygen, nitrate, and phosphate suggests that phosphate highly affects the denitrification performance of the network.
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