Title page for ETD etd-22398-215911


Type of Document Master's Thesis
Author Robinson, Paul S.
Author's Email Address robinson@stnick.me.vt.edu
URN etd-22398-215911
Title Development of Methodologies for the Noninvasive Estimation of Blood Perfusion
Degree Master of Science
Department Mechanical Engineering
Advisory Committee
Advisor Name Title
Diller, Thomas E. Committee Chair
Diller, Thomas E. Committee Member
Scott, Elaine P. Committee Member
Veit, Hugo P. Committee Member
Keywords
  • blood perfusion
  • biothermal modeling
  • biothermal heat transfer
  • parameter estimation
  • heat flux sensors
Date of Defense 1998-01-29
Availability restricted
Abstract
This work focuses on the development of a system to

noninvasively estimate blood perfusion using thermal methods. This is

accomplished by the combination of a bioprobe, biothermal model, and

parameter estimation techniques. The probe consists of a heat flux

sensor and surface thermocouple placed in contact with tissue

while the opposite side is cooled by jets of room temperature air. The

biothermal model predicts the temperature and heat flux within tissue

and probe based upon the input of blood perfusion and the thermal contact

resistance between probe and tissue. Parameter estimation techniques

are developed that use the model to simultaneously estimate blood

perfusion and contact resistance based on experimental heat flux

and/or temperature. A gradient based system minimizes a sum of

squares error function based on either or both heat flux and

temperature. This system

is tested on human forearms and in controlled flow rate experiments

using tissue phantoms. Blood perfusion estimates from the controlled

experiments are positively correlated with experimental flow rate.

Experimental measurements and statistical analysis show distinct

variations in the heat flux signal and rises in perfusion estimates

with increasing flow rate. This research validates the use of

thermal and parameter estimation methods to develop a practical,

noninvasive probe to clinically measure blood perfusion.

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