Type of Document Dissertation Author Cotton, John Rowland III Author's Email Address firstname.lastname@example.org URN etd-32298-104435 Title Mechanical modeling of vestibular hair cell bundles Degree PhD Department Engineering Science and Mechanics Advisory Committee
Advisor Name Title Batra, Romesh C. Inman, Daniel J. Peterson, Ellengene H. Ragab, Saad A. Grant, John Wallace Committee Chair Keywords
- Hair cell ciliary bundles
- finite element analysis
- vestibular sense
Date of Defense 1998-01-30 Availability unrestricted AbstractHair cells are transducers found found in the inner ear of vertebrates. They convert a mechanical signal, detected by the deflection of a bundle of cilia extending from their top surface, into an electrochemical signal. This dissertation studies the mechanical influence of the structure and materials on the function of the cells.
I introduce two methods to conduct the mechanical analysis. The first uses strength of materials formulae to solve the simplified hair cell bundle models. The second is a finite element analysis, used to better account for the observed complexity of the structure.
I then use these two techniques to build a fundamental understanding of the hair cell bundle structure. By first studying simplified models, then adding complexity, the effects of geometric and material variation can be deduced.
I then study three actual bundles. These are all taken from vestibular organs of turtles, two from the posterior semicircular canal and one from the utricle. I present estimations of stiffness, tip link tensions, and nonlinear response.
Finally, I investigate a single cilium forced by a fluid flow. The problem is solved by finite difference technique. Three different initial conditions are solved.
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