Title page for ETD etd-32498-13160


Type of Document Dissertation
Author Wojcik, Janet Regina
Author's Email Address jwojcik@vt.edu
URN etd-32498-13160
Title Effect of Carbohydrate-Protein Beverage on Glycogen Resynthesis and Muscle Damage Induced By Eccentric Resistance Exercise
Degree PhD
Department Human Nutrition, Foods, and Exercise
Advisory Committee
Advisor Name Title
Rankin, Janet L. Walberg Committee Chair
Gwazdauskas, Francis C. Committee Member
Schulman, Robert S. Committee Member
Thye, Forrest W. Committee Member
Williams, Jay H. Committee Member
Keywords
  • creatine kinase
  • 3-methylhistidine
  • insulin
  • testosterone
  • cortisol
Date of Defense 1998-04-17
Availability unrestricted
Abstract
This study examined effects of carbohydrate (C), carbohydrate-protein (CP), or placebo (P) beverages following eccentric resistance exercise on muscle damage by serum creatine kinase (CK), muscle protein breakdown by urinary 3-methylhistidine (3MH), muscle soreness, isokinetic muscle strength, muscle glycogen resynthesis, and serum hormones. Untrained males (N=26) underwent a 9-day controlled meat-free diet and 24 hr urine collections. To reduce glycogen, subjects cycled for 40 min at 70% of VO2peak followed by 5 cycling sprints on day 4 evening. On day 5, fasted subjects performed 100 eccentric leg flexions at 120% of 1-RM and drank C (n=8, 1.25 g C/kg), CP (n=9, 0.875 g C/kg, 0.375 g protein/kg), or P (n=9) beverages immediate post-exercise (IPE) and 2 hr later. Muscle biopsies were taken IPE on day 5, and days 6 and 8 mornings. Blood was obtained days 4-10 fasted plus IPE, 3 hr, and 6 hr post-exercise on day 5. At 3 hr on day 5, insulin was higher for CP (24.6 ( 15.5 &#181;IU/ml) and C (17.2 +/- 10.9 &#181;IU/ml) than P (5.3 +/- 0.4 &#181;IU/ml, p<.05). Glycogen was low on day 5, partially recovered on day 6, and normal by day 8 (p<.01) with no difference among groups. Isokinetic quadriceps peak torque at 60o/s decreased 24% on day 6 and remained depressed by 21% on d 8 (p<.01) for all groups. Soreness peaked on day 7 and CK on day 8 (p<.01) with no differences by group. CK increased (p<.01) over day 5 (delta CP 24.6 +/- 19.1, delta P 39.2 +/- 71.6, delta C 70.8 +/- 60.4 U/L) and was highest for C (p<.05). On day 5, CP had lowest 3MH (193.0 +/- 13.8 &#181;mol/d) versus C (251.1 +/- 22.5 &#181;mol/d, p<.05). Testosterone at 3 hr on day 5 was lower for C (4.2 +/- 0.3 ng/ml) and CP (4.3 +/- 0.3 ng/ml) versus P (5.1 +/- 0.2 ng/ml, p<.05). In summary, glycogen, muscle strength and soreness were unaffected by beverage. However, a CP beverage may be beneficial for reducing muscle damage and protein breakdown on the day of eccentric resistance exercise.

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