Type of Document	Master's Thesis
Author	Shifflett, D. Edward Jr.
Author's Email Address	gfanconi@compuserve.com
URN	etd-43098-1124
Title	Physiological Responses in OSA Patients to Ramping Exercise After CPAP Treatment
Degree	Master of Science
Department	Human Nutrition, Foods, and Exercise
Advisory Committee	Advisor Name Title Gregg, John M. Ward, Christopher W. Zedalis, Donald Herbert, William G. Committee Chair
Keywords	Obstructive sleep apnea exercise physiological repsonse CPAP
Date of Defense	1998-04-24
Availability	unrestricted
Abstract (ABSTRACT) Continuous positive airway pressure (CPAP) is the primary therapy administered for those afflicted with obstructive sleep apnea (OSA). We examined the effects of CPAP therapy on physiological variables during a ramped exercise. The five male, OSA patients had mean values and standard deviations for RDI=60.7 +/- 19.1, BMI=29.9 +/- 2.9, and age=56 +/- 16.1 yr. Subjects were examined before and after 4 wk of CPAP therapy. After 4 wk of CPAP therapy, patient responses to exercise showed a 17.6%, (p<0.05) improvement in rating of perceived exertion (RPE) at identical power outputs (60% of the individual's apparent functional capacity). Statistical significance was not attained (p>0.05) upon analysis of the following parameters at 60% of the individuals maximum workload although there was a trend showing a decrease in these variables: heart rate (6% improvement), VO2 (11.7% improvement) systolic blood pressure (4% improvement), and rate pressure product (8.6% improvement). This data shows that the decrease in RPE during 60% of the individual's maximum predicted HR reserve corresponded with an increase in sleep quality (mean increase of 40%, 3.2 units) as measured by the Pittsburgh Sleep Quality Index before and after 4 wk of CPAP therapy. It was concluded that the improvement in exercise tolerance could be attributed to the subjective feelings of improved sleep quality after 4 wk of CPAP therapy. Key Words: Obstructive sleep apnea---CPAP--- exercise---physiological responses.
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