Type of Document	Master's Thesis
Author	Owellen, Michael C.
Author's Email Address	mowellen@vt.edu
URN	etd-62997-145654
Title	Biotribology: The Effect of Lubricant and Load on Articular Cartilage Wear and Friction
Degree	Master of Science
Department	Mechanical Engineering
Advisory Committee	Advisor Name Title Eiss, Norman S. Jr. Gregory, Eugene M. Veit, Hugo P. Furey, Michael J. Committee Chair
Keywords	tribology articular cartilage wear joint lubrication
Date of Defense	1997-07-21
Availability	unrestricted
Abstract This paper presents a biotribological study on cartilage wear and friction, using a system of cartilage-on-stainless steel. This study is a part of the ongoing biotribology research by Dr. Furey at the Virginia Polytechnic Institute and State University. Two loads (65 N and 20 N) and three lubricants (saline reference, reference + hyaluronic acid, and bovine synovial fluid) were tested and evaluated using several analysis techniques. These techniques included wear analysis by hydroxyproline measurement, scanning electron microscopy (SEM), histologic sectioning and staining, numerical analysis of friction and specimen displacement data, and Fourier transform infrared (FTIR) analysis. Biochemical wear analysis showed that, under high load, the saline reference generated the most wear, hyaluronic acid produced less wear, and bovine synovial fluid produced the least. Wear was sensitive to load with all three lubricants, but was not significantly affected by the lubricant under low load. SEM photographs and histologic sections showed evidence of plowing and surface delamination, as well as another wear mechanism that produced wear markings perpendicular to the direction of sliding. Opaque films remained on the polished stainless steel disks after saline and hyaluronic acid tests, but not after synovial fluid tests. FTIR analysis of these films, as well as fresh and worn cartilage, showed that the cartilage experienced chemical changes during sliding.
Files	Filename       Size       Approximate Download Time (Hours:Minutes:Seconds)     28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access    01_COVER.PDF 19.91 Kb 00:00:05 00:00:02 00:00:02 00:00:01 < 00:00:01   02_INTRO.PDF 8.59 Kb 00:00:02 00:00:01 00:00:01 < 00:00:01 < 00:00:01   03_LITREV.PDF 174.92 Kb 00:00:48 00:00:24 00:00:21 00:00:10 < 00:00:01   04_TECHNIQ.PDF 60.14 Kb 00:00:16 00:00:08 00:00:07 00:00:03 < 00:00:01   05_RESULTS1.PDF 96.38 Kb 00:00:26 00:00:13 00:00:12 00:00:06 < 00:00:01   06_RESULTS2.PDF 1.07 Mb 00:04:56 00:02:32 00:02:13 00:01:06 00:00:05   07_RESULTS3.PDF 2.60 Mb 00:12:01 00:06:11 00:05:24 00:02:42 00:00:13   08_RESULTS4.PDF 978.84 Kb 00:04:31 00:02:19 00:02:02 00:01:01 00:00:05   09_RESULTS5.PDF 315.58 Kb 00:01:27 00:00:45 00:00:39 00:00:19 00:00:01   10_DISCUSSN.PDF 29.69 Kb 00:00:08 00:00:04 00:00:03 00:00:01 < 00:00:01   11_CONCLUSN.PDF 23.56 Kb 00:00:06 00:00:03 00:00:02 00:00:01 < 00:00:01   12_APPENDIX.PDF 39.28 Kb 00:00:10 00:00:05 00:00:04 00:00:02 < 00:00:01

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