Title page for ETD etd-72498-21309


Type of Document Master's Thesis
Author Baloglu, Erkan Jr.
Author's Email Address ebaloglu@vt.edu
URN etd-72498-21309
Title A New Synthesis of Taxol®, from Baccatin III
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
Kingston, David G. I. Committee Chair
Calter, Michael A. Committee Member
Deck, Paul A. Committee Member
Keywords
  • taxol
  • paclitaxel
  • baccatin
  • cancer
  • anticancer drugs
  • chemotherapy
Date of Defense 1998-08-07
Availability unrestricted
Abstract
Taxol®,, an important anticancer drug, was first isolated in extremely low yield

from the bark of the western yew, Taxus brevifolia. The clinical utility of Taxol has

prompted a tremendous effort to obtain this complex molecule synthetically. Due to the

chemical complexity of Taxol, its commercial production by total synthesis is not likely to

be economical.

Another natural product, 10-deacetyl baccatin III, is readily available in higher

yield. Several methods have been reported for the synthesis of Taxol by coupling baccatin

III and the N-benzoyl-b-phenylisoserine side chain. A new method for the synthesis of

Taxol from baccatin III is reported, and this method is compared with other methods.

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