Scholarly
    Communications Project


Document Type:Master's Thesis
Name:Cindy Marie Swancott
Email address:lovern@bellatlantic.net
URN:1998/00460
Title:EFFECTS OF LOW AND HIGH SODIUM CHLORIDE DIETS AND FUROSEMIDE ADMINISTRATION ON CARDIAC FUNCTION, PLASMA ELECTROLYTE CONCENTRATIONS, AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
Degree:MASTER OF SCIENCE
Department:VETERINARY MEDICAL SCIENCES
Committee Chair: WILLIAM S.SWECKER
Chair's email:cvmwss@vt.edu
Committee Members:Marth Moon
John Lee
Keywords:Low sodium, High sodium, Furosemide, Renin-Angiontensin-Aldosterone, Cardiac, Plasma Electrolytes
Date of defense:April 14, 1998
Availability:Release the entire work for Virginia Tech access only.
After one year release worldwide only with written permission of the student and the advisory committee chair.

Abstract:

EFFECTS OF LOW AND HIGH SODIUM CHLORIDE DIETS AND FUROSEMIDE ADMINISTRATION ON CARDIAC FUNCTION, PLASMA ELECTROLYTE CONCENTRATIONS, AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM CINDY M. SWANCOTT (ABSTRACT) Congestive heart failure is commonly treated with a low sodium diet and diuretic. The purpose of this treatment is the reduction of preload, or blood volume presented to the diseased cardiac muscle. The purpose of this study was to assess the roles of dietary sodium and furosemide on cardiac function, plasma electrolyte concentrations, and the renin-angiotensin-aldosterone system, in healthy canines. Twenty mixed-breed canines were allotted to one of four groups, Group I - Dogs fed low sodium diet (0.08% sodium), Group II - Dogs fed high sodium diet (1.0% sodium), Group III - Dogs fed low sodium (0.08%) and treated with furosemide (2 mg/kg orally (PO) every twelve hours (BID)), and Group IV - Dogs fed high sodium (1.0%) and furosemide ( 2 mg/kg PO BID). Cardiac function was assessed via echocardiography on days 0, 21,and 53. Plasma electrolyte concentrations were measured on days 0, 21, and 35. Activation of the renin-angiotensin-aldosterone system was evaluated on days 0, 21, 35, and 53. Low and high sodium diet with and without furosemide treatment did not alter cardiac function, plasma sodium, or plasma potassium concentrations. However, furosemide treatment combined with a low sodium diet resulted in the lowest plasma chloride concentrations, on days 21 and 35 (p<0.05). Furthermore, furosemide treatment resulted in significant alterations in the renin-angiotensin-aldosterone system, on days 21, 35, and 53, (p < 0.0001). Furosemide treatment significantly increased renin activity and aldosterone concentration. The interaction between furosemide and the low sodium diet yielded a greater increase in plasma renin activity and plasma aldosterone concentrations than furosemide administration with the high sodium diet. These results suggest direct activation of the renin-angiotensin-aldosterone system by furosemide. Future research is warranted in congestive heart failure subjects, due to the adverse affects of decreased plasma chloride concentrations and activation of the renin-angiotensin-aldosterone system.

List of Attached Files

thesisF.pdf

At the author's request, all materials (PDF files, images, etc.) associated with this ETD are accessible from the Virginia Tech network only.


The author grants to Virginia Tech or its agents the right to archive and display their thesis or dissertation in whole or in part in the University Libraries in all forms of media, now or hereafter known. The author retains all proprietary rights, such as patent rights. The author also retains the right to use in future works (such as articles or books) all or part of this thesis or dissertation.