|Document Type:||Master's Thesis|
|Name:||Katharine Gage Lahti|
|Title:||Estimation of Variance Components in Finite Polygenic Models and Complex Pedigrees|
|Degree:||Master of Science|
|Committee Chair:||Ina Hoeschele|
|Committee Members:||David Notter|
|William E. Vinson|
|Keywords:||finite polygenic model, nonadditive genetic variance, Bayesian methods|
|Date of defense:||June 5, 1998|
|Availability:||Release the entire work for Virginia Tech access only.
After one year release worldwide only with written permission of the student and the advisory committee chair.
Various models of the genetic architecture of quantitative traits have been considered to provide the basis for increased genetic progress. The finite polygenic model (FPM), which contains a finite number of unlinked polygenic loci, is proposed as an improvement to the infinitesimal model (IM) for estimating both additive and dominance variance for a wide range of genetic models. Analysis under an additive five-loci FPM by either a deterministic Maximum Likelihood (DML) or a Markov chain Monte Carlo (MCMC) Bayesian method (BGS) produced accurate estimates of narrow-sense heritability (0.48 to 0.50 with true values of h2 = 0.50) for phenotypic data from a five-generation, 6300-member pedigree simulated without selection under either an IM, FPMs containing five or forty loci with equal homozygote difference, or a FPM with eighteen loci of diminishing homozygote difference. However, reducing the analysis to a three- or four-loci FPM resulted in some biased estimates of heritability (0.53 to 0.55 across all genetic models for the 3-loci BGS analysis and 0.47 to 0.48 for the 40-loci FPM and the infinitesimal model for both the 3- and 4-loci DML analyses). The practice of cutting marriage and inbreeding loops utilized by the DML method expectedly produced overestimates of additive genetic variance (55.4 to 66.6 with a true value of sigma squared sub a = 50.0 across all four genetic models) for the same pedigree structure under selection, while the BGS method was mostly unaffected by selection, except for slight overestimates of additive variance (55.0 and 58.8) when analyzing the 40-loci FPM and the infinitesimal model, the two models with the largest numbers of loci. Changes to the BGS method to accommodate estimation of dominance variance by sampling genotypes at individual loci are explored. Analyzing the additive data sets with the BGS method, assuming a five-loci FPM including both additive and dominance effects, resulted in accurate estimates of additive genetic variance (50.8 to 52.2 for true sigma squared sub a = 50.0) and no significant dominance variance (3.7 to 3.9) being detected where none existed. The FPM has the potential to produce accurate estimates of dominance variance for large, complex pedigrees containing inbreeding, whereas the IM suffers severe limitations under inbreeding. Inclusion of dominance effects into the genetic evaluations of livestock, with the potential increase in accuracy of additive breeding values and added ability to exploit specific combining abilities, is the ultimate goal.
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