Lack of Anti-Excitatory Activity in Cerebrospinal Fluid from Secondary Progressive Multiple Sclerosis Patients

Hubertus Köller

Published: May 3, 2000

Factors in cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (MS) interfere with neuronal Na ⁺ channels and thereby reduce neuronal excitability. The nature of such factors is still unknown. The CSF from patients with secondary progressive MS, however, did not contain this anti-excitatory activity, and therefore further efforts in the identificati on of these factors should concentrate on molecules specifically present in CSF during relapses.

Keywords: Multiple Sclerosis; Cortical Neurons; Sodium Current; Culture; Electrophysiology; Rats