Clinical Study of a Urinary Competitve ELISA for Neural Thread
Protein in Alzheimer Disease
Michael Munzar
Suzanna Levy
Robert Rush
Paul Averback
READ
FULL ARTICLE
PDF
Published: July 2001
AD7C-NTP (neural thread protein)is a ~41 kD brain protein that
is selectively elevated in Alzheimer disease (AD). AD7C-NTP is
associated with the pathologic changes of AD, and over expression
of the AD7C-NTP gene is asso- ciated with cell death similar to
that found in the AD brain. A newly developed competitive ELISA
(enzyme-linked immunosorbent assay)was tested in urine samples from
patients with AD, patients with non-AD dementia, and healthy normal
individuals. Mean assay measurement in the AD group (30.1 ±
10.8)was significantly higher than in the non-AD dementia control
group (13.4 ± 3.4)and in the nondementia control group (14.8
± 5.2)(P <0.001). Mean assay measurement in early-AD
cases (25.3 ± 7.6)was significantly lower than in other AD
cases (33.9 ± 11.4). Levels of more than 18 units were found
in 89% of overall AD cases and in 10% of overall controls. The
results further validate urinary AD7C-NTP as a biochemical marker
for AD and indicate that the competitive ELISA-format AD7C-NTP test
in urine is an accurate method for determining AD7C-NTP levels in
AD.
Keywords:
botulinum toxin type A (BoNT/A), antibodies,
cervical dystonia (CD), therapy
|
About
Contact
