Characterizing Neuropathies Associated
With Monoclonal Gammopathy of
Undetermined Significance (MGUS): A
Framework Consistent With Classifying
Injuries According to Fiber Size
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Published: May 2002
Neuropathies associated with monoclonal gammopathy of undetermined
significance (MGUS) occur frequently in
the elderly. Data from 42 consecutive elderly patients with a MGUS-associated
neuropathy—12 patients with IgM
MGUS,25 patients with IgG MGUS,5
patients with IgA MGUS — were evaluated prospectively using quantifiable
clinical criteria and quantitative sensory
testing. Results consistent with preferential injury to large fibers were found
in patients with IgM isotypes (
P
< .005)
but not in patients with IgG isotypes (
P
< .0005 to .0004). These findings support an immunologic origin for at least
some MGUS-associated neuropathies
and provide information important for
the clinical evaluation of neuropathies
in the elderly.
Keywords:
fiber size, immunologic,
monoclonal gammopathy of
undetermined significance (MGUS),
neuropathy, quantitative sensory testing
(QST)
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