Characterizing Neuropathies Associated
With Monoclonal Gammopathy of
Undetermined Significance (MGUS): A
Framework Consistent With Classifying
Injuries According to Fiber Size
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Published: May 2002
Neuropathies associated with monoclonal gammopathy of undetermined
significance (MGUS) occur frequently in
the elderly. Data from 42 consecutive elderly patients with a MGUS-associated
neuropathy12 patients with IgM
MGUS,25 patients with IgG MGUS,5
patients with IgA MGUS were evaluated prospectively using quantifiable
clinical criteria and quantitative sensory
testing. Results consistent with preferential injury to large fibers were found
in patients with IgM isotypes (
P
< .005)
but not in patients with IgG isotypes (
P
< .0005 to .0004). These findings support an immunologic origin for at least
some MGUS-associated neuropathies
and provide information important for
the clinical evaluation of neuropathies
in the elderly.
Keywords:
fiber size, immunologic,
monoclonal gammopathy of
undetermined significance (MGUS),
neuropathy, quantitative sensory testing
(QST)
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